Get Ready for NFL Week 10: Fantasy Football Tips, Betting Picks, and Must-See Matchups

Favorite bet: 49ers -3 The Jaguars are struggling to find consistency on offense, and the 49ers have the advantage on both sides of the ball. Take San Francisco to cover on the road in Week 10.

The NFL season is in full swing, and with each passing week, the stakes get higher. As teams jockey for playoff position, every game becomes crucial. In preparation for Week 10, Pro Football Focus (PFF) has analyzed the upcoming matchups and produced their Best Bets Tool to help fans make informed decisions when placing their bets.

One of the key matchups to watch in Week 10 is the Indianapolis Colts vs. New England Patriots game. The Patriots, led by head coach Bill Belichick, are slight underdogs at +1.5, but history has shown that Belichick has had success against the Colts regardless of who is at quarterback. Additionally, the Patriots defense, under Belichick’s leadership, poses a significant challenge for the Colts’ offense. PFF’s Best Bets Tool suggests taking the Patriots as slight underdogs and expecting them to secure a win on foreign soil.

Another intriguing matchup is the Houston Texans vs. Cincinnati Bengals game, with the Bengals favored by 7 points. The matchup to watch in this game is Texans LT Laremy Tunsil against Bengals EDGE Trey Hendrickson. Both players are ranked among the top performers in their respective positions, making this a compelling battle to keep an eye on. PFF’s Best Bets Tool recommends taking the Texans +7 and expecting a closely contested game in Cincinnati.

The New Orleans Saints are also slated to face the Minnesota Vikings in Week 10, with the Saints favored by 2.5 points. The matchup to watch in this game is between Vikings WR Jordan Addison and Saints CB Paulson Adebo. Adebo, who has been enjoying a breakout season, is expected to face a tough challenge in covering Addison, making this an exciting matchup to watch. PFF’s Best Bets Tool advises taking the Saints -2.5 and expecting them to win and cover on the road.

In the matchup between the Green Bay Packers and the Pittsburgh Steelers, the Steelers are favored by 3 points. The matchup to watch in this game is between Steelers WR Diontae Johnson and Packers CB Jaire Alexander. This promises to be a closely contested battle between two top talents in their respective positions. PFF’s Best Bets Tool recommends taking the Steelers -3 with confidence.

Lastly, the San Francisco 49ers will be facing the Jacksonville Jaguars, with the 49ers favored by 3 points. The matchup to watch in this game is between Jaguars LT Cam Robinson and 49ers EDGE Chase Young. Young, who was recently acquired by the 49ers, will have his first game with his new team and is expected to face a tough test in Robinson. PFF’s Best Bets Tool suggests taking the 49ers -3, as they are favored to win and cover on the road.

As Week 10 approaches, football fans and bettors can use PFF’s Best Bets Tool to gain valuable insights and make well-informed decisions when placing their bets on the upcoming NFL matchups.